3D printing of porous Ti6Al4V bone tissue engineering scaffold and surface anodization preparation of nanotubes to enhance its biological property

Abstract Porous structures and surface morphology of bone tissue scaffolds play an important role in improving the biocompatibility antibacterial properties for repair. In this study, we investigated effect different anodic oxidation parameters on nanotubes 3D printed porous titanium scaffolds. Micron-scale pores were fabricated by printing first, then nano-scale tubes obtained via anodizing treatments. The results demonstrated that depended time voltage, respectively. Longer led to formation circle-like nanotubes, diameter increased with voltage. anodized at 30 V showed best cell proliferation potential. presence scaffold altered adhesion bacteria so it improved scaffold. drug-loading ability scaffold, which are used loading minocycline drugs. proposed Ti6Al4V modification obvious effect, is expected have a promising application prosthesis.